The value of PRNCR1 in the diagnosis and prognosis of prostate cancer

Abstract

Objective To analyze the value of PRNCR1 in the early diagnosis and prognosis of prostate cancer. Methods From January 2012 to October 2015, the prostate cancer (n=45) and benign prostatic hyperplasia (n=88) tissues of surgical group were enrolled into PRNCR1 group and RNA test. Results The sensitivity of the 84.4%(38/45) PRNCR1 RNA test, specificity 90.9%(80/88), positive predictive value 82.6%(38/46), and negative predictive value of 92% (80/87), the coincidence rate was 88.7%(118/133), PRNCR1 in prostate cancer was higher than that of adjacent tissues and benign prostatic hyperplasia tissues, the difference was statistically significant (P<0.05). Within 2 years, tumor recurrence and metastasis object of 30 death cases of PRNCR1 cells was higher than that of 2 years without recurrence, metastasis, the object of 15 death cases, the difference was statistically significant(P<0.05). Conclusions The expression of PRNCR1 is valuable in the diagnosis of prostate cancer, and the high expression of PRNCR1 is associated with poor prognosis. Key words: Prostatic Neoplasms; RNA; Prognosis