The value of pelvic ultrasound in gonadotropin-releasing hormone agonist treated girls with idiopathic central precocious puberty

Abstract

Objective To study the parameters characteristics and clinical value of pelvic ultrasound(PU) in gonadotropin-releasing hormone agonist(GnRHa) treated girls with idiopathic central precocious puberty(ICPP). Methods 47 girls with ICPP were selected as ICPP group, treated by GnRHa, accepted PU before and after treatment, and measured the sex hormone levels by the immune chemiluminescence method.The results were compared with 55 cases of normal sexual development girls(normal group). Results The uterine volume[(5.604±1.146)mL], follicle maximum diameter[(0.709±0.116)cm]and ovarian volume[(2.775±0.963)mL]in ICPP group were obviously increased than those in the normal group[(1.734±0.434)mL, (0.294±0.070)cm, (0.893±0.234)mL], the differences were statistically significant (t=23.179, 22.059, 14.015, all P<0.05). The uterine volume[(2.644±0.870)mL], follicle maximum diameter[(0.425±0.176)cm]and ovarian volume[(1.655±0.219)mL] in ICPP girls after treatment were obviously reduced than those before treatment, the differences were statistically significant (t=33.645, 22.809, 9.874, all P<0.05). The peak of luteinizing hormone[(8.311±3.671)IU/L], follicle stimulating hormone[(3.945±1.516)IU/L] and the estradiol level[(45.094±15.819)pmol/L] in ICPP girls after treatment were significantly lower than those before treatment, the differences were statistically significant (t=14.763, 42.068, 51.714, all P<0.05). Conclusion PU can accurately diagnose ICPP noninvasively, and dynamicly monitor the curative effect of GnRHa for ICPP, provide reference for clinic. Key words: Ultrasonic examination; Gonadotropin-releasing hormone agonist; Precocious puberty, idiopathic