Significance of Kisspeptin levels in diagnosis and therapeutic evaluation of idiopathic central precocious puberty in girls

Abstract

Objective To explore the significance and value of Kisspeptin in the diagnosis and therapeutic evaluation for idiopathic central precocious puberty(ICPP) in girls. Methods Twenty-four girls with ICPP and 21 girls with premature thelarche(PT) who were hospitalized in the Children's Hospital of Jiangxi Province from Jun.2012 to Jan.2013 were selected as ICPP group and PT group, and 25 healthy girls were selected as healthy control group.The coagulation vein blood in ICPP girls before treatment and after 6 months treatment and PT girls and healthy girls were collected, and enzyme linked immunosorbent assay was used to detect the plasma Kisspeptin level, and t test was used to analyze the differences among the 4 groups. Results The Kisspeptin level of girls with ICPP[(1.80±0.13) μg/L] was apparently higher than that of PT groups [(1.41±0.10) μg/L] and healthy control group[(1.39±0.13) μg/L], and the differences were statistically significant(t=10.974, 14.787, all P=0.000). However, the difference of Kisspeptin between PT group and healthy control group was not statistically significant(t=10.970, P=0.095). In addition, the Kisspeptin level of ICPP girls who undewent 6-month treatment [(1.49±0.15) μg/L ]was significantly lower than that before treatment, and the difference was statistically significant(t=10.80, P<0.05); but, compared with PT group and healthy control group, there was no significant difference(t=6.32, P=0.060; t=7.44, P=0.214). Conclusions Kisspeptin level is related with pubertal development, and it can be used as an important evidence in ICPP diagnosis and an important parameter in ICPP therapeutic evaluation. Key words: Kisspeptin; Idiopathic central precocious puberty; Premature thelarche