Abstract
That estrogenic substances have an inhibiting effect on the gonadotrophic activity of the pituitary of mammals has been amply demonstrated in endocrine literature. The use of stilbestrol as a “fattening” hormone in chickens has shown that a pronounced modification of the rate of function of the pituitary may be accomplished. Implants of as little as 15 mgs. of stilbestrol into males will cause complete regression of the testes and subsequently the comb, while larger doses will lead to a cessation of growth and will induce conditions in some instances resembling surgical hypophysectomy (Nalbandov & Card, 1943). These observations led to the idea that the physiological inhibition of the pituitary by estrogen may be used in the laboratory in place of surgical hypophysectomy. The advantage of the former lies in the fact that it is possible to make implants into large numbers of animals in a very short time,
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