Abstract
THE search for exogenously administered agents which will control pituitary gonadotrophic function has revealed that inhibition may be produced by estrogens, androgens and progesterone when large doses are given. Mild stimulation may result from administering small amounts of some of these steroids. Clinical application of these agents in instances where pituitary suppression or stimulation is desired is limited by their marked sex hormone effects. For example, it would be ideal to cut off pituitary stimulation to the ovary in endometriosis or premature puberty. However, (1) estrogens cannot be used because amounts large enough to suppress pituitary gonadotrophins aggravate these conditions; (2) androgens are limited in usefulness by their virilizing effects; and (3) the dosage of progesterone is too large to be practicable. No potent hypophyseal stimulator is known. Therefore, a number of substances unlikely to exhibit marked estrogenic or androgenic activity were screened to determine their ability to d...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
