Abstract
Thiamine propyl disulfide (TPD), a lipotropic derivative related to thiamine, has a specific ability to cross the biological membrane. In the present paper the mechanism of reduction and uptake of TPD in blood is described. TPD is converted to thiamine by a heat stable factor(s) in blood cells and to a slight extent by plasma. This reducing ability of blood cells is increased with the aid of plasma. From the fact that this conversion is inhibited by p- chloromercuribenzoic acid, it is postulated that SH groups may play a major role in this reduction process. A possible explanation on the mechanism for accumulation of TPD in blood cells is presented.
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