Abstract
By investigating the reaction of papain with thiamine derivatives of various disulfide types following facts were found.1. The amount of thiamine formed in the reaction of papain with thiamine propyl disulfide (TPD) or thiamine disulfide (TDS) was nearly equimolar.2. Remarkable differences were found between asymmetric disulfide compounds of thiamine such as TPD and symmetric ones such as TDS in the inhibitory action on papain, the former being more marked than the latter.3. Inhibition of papain by TPD or TDS was completely recovered by cysteine.4. The reaction product of papain with TPD or TDS was investigated by paper chromatography. In the case of TDS, thiamine was detected at the starting point, whereas no thiamine was found in the case of TPD.
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