Abstract
The hydrogen peroxide (H2O2) hemolysis test has been widely used as an index of vitamin E deficiency in animals and humans. In the present study, the relationship between the degree of H2O2 hemolysis and serum vitamin E level was investigated in adult patients with anemia due to various etiologies. H2O2 hemolysis values were found to be abnormally elevated in 4 cases of hereditary spherocytosis, 11 of 40 cases of iron deficiency anemia, 2 of 10 cases of anemia due to renal insufficiency and 1 of 5 cases of anemia due to infection. The elevation of H2O2 hemolysis in cases of anemia due to renal insufficiency or infection was not related to the decrease of serum vitamin E level. However, mean serum vitamin E levels in cases of hereditary spherocytosis and iron deficiency anemia were statistically lower than those of healthy adults. These experiments suggest that low serum vitamin E levels in cases of hereditary spherocytosis and iron deficiency anemia play some role in the cause of fragility of the red blood cells in these anemias.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
