Abstract
AbstractThe enzymes responsible for the metabolism of methylated xanthines suah as theophylline, theobromine, and caffeine have until now escaped identification (1, 2). However, a sensitive radiometric method of analysis of theophylline metabolism (3) was made possible by the synthesis and purification of 8‐14C‐theophylline (14C‐Theo). 14C‐Theo was synthesized by the incorporation of 14C from 14C‐formic acid into the 8‐position of the purine ring. Purification of the 14C‐Theo was accomplished by subjecting the crude produot to cation‐exchange column chromatography with AG50W‐X12, 50–100 mesh resin of the hydrogen ion form.
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