The suppressive effects of parecoxib on the patients with postoperative hyperalgesia after remifentanilbased Anesthesia

Abstract

Objective To study the suppressive effects of parecoxib on postoperative hyperalgesia after remifentanil-based anesthesia. Methods 60 ASA grade Ⅰ - Ⅱ patients undergoing selective laparoscopic operations were randomly divided into two groups (n = 30) :controlled group (group A) and parecoxib group B (group B). Midazolam(0.05 mg/kg) ,remifentanil (1μg/kg) ,propofol (2 mg/kg) and atracrium (0. 6 mg/kg) were administered for anesthesia induction, and 0. 2 ～ 0. 4 μg/( kg · min ) remifentanil and 1.5 % ～ 3% sevoflurane were given for anesthesia maintenance in the two groups. At skin closure parecoxib 40 mg was intravenous injected in group B ,and group A received no drug infusion. MAP, HR and SpO2 was recorded at the time points of entering the operation room ( T0 ), completion of the operation ( T1 ), wake up ( T2 ) , extubation ( T3 ), 10 minutes after extubation ( T4 ) and 30 minutes after extubation ( T5 ). The time of awake, the time of extubation and the adverse effects were recorded. The Ramsay sedation score and VRS score were evaluated. Results In group A,MAP and HR of T2, T3 T4 and T5 were remarkable higher than T0 ( P ＜ 0. 05 ) , and also higher than those of group B ( P ＜ 0. 05 ). The Ramsay sedation score and VRS score in group B were much better than those in group A ( P ＜ 0. 05 ). Compared with group A, the rate of restlessness of group B was obviously lower( P ＜ 0. 05 ). Con-clusion Parecoxib has significant suppressive effect on patients with postoperative hyperalgesia after remifentanil-based anesthesia. Key words: Parecoxib; Remifentanil; Hyperalgesia