Abstract
The development of new biomaterials with improved properties is becoming increasingly important in a wide range of applications. However, some of the most sought-after properties are anti-microbial properties, which can help prevent unwanted wound infections, especially in the face of growing antibiotic resistance of bacteria. The aim of the study was to study the effect of antimicrobial biomaterials based on calcium alginate, as a polymer system of local prolonged delivery of quaternary ammonium compounds, on reference and clinical strains of microorganisms. Samples of antimicrobial biomaterials contained decamethoxin (0.03-0.07 wt%), and polymers (polyvinyl alcohol and calcium alginate). Reference and clinical strains of Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa were used for the study. The sensitivity of strains of microorganisms was determined by the disk-diffusion method according to the generally accepted method. The result of antimicrobial activity was assessed after 24 hours. The mean (M), the mean error of the mean (± m), and the criterion for the significance of differences (p) were calculated. The presence of differences between the research data was assessed by the Student's t-criterion. The results were considered reliable at p<0.05. High antimicrobial properties of the studied samples of antimicrobial biomaterials based on calcium alginate and decamethoxin have been established. It was revealed that the samples of polymeric biomaterials have a higher activity against gram-positive microorganisms compared to gram-negative strains. The composition is not inferior to the antimicrobial effect of a solution of decamethoxin and chlorhexidine in relation to all strains of microorganisms.
Highlights
Advances in medicine in the modern world allow to realize the human desire to improve the quality and duration of life [7, 8, 9]
Infections associated with health care (IAHC) are an urgent problem in the field of health care, as they complicate the course of the disease, increase the risk of mortality and create a high financial burden on the health care system
Reference strains of the Museum of Living Cultures of the Department of Microbiology, Virology and Immunology of National Pirogov Memorial Medical University, Vinnytsya Staphylococcus aureus АТСС 25923, Staphylococcus aureus ATCC 25927, Escherichia coli АТСС 25922, Escherichia coli ATCC 35213, Klebsiella pneumoniae ATCC 708603, Pseudomonas aeruginosa ATCC 27853, Acinetobacter baumannii ATCC ВАА-747 and clinical isolates Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii were used for the study
Summary
Advances in medicine in the modern world allow to realize the human desire to improve the quality and duration of life [7, 8, 9]. A significant role in achieving these goals is played by the success of the development and use of new biomaterials used in medicine to support the vital functions and normal functioning of the body [12, 17, 20]. Biomaterials are materials that are in constant contact with body tissues, so they must meet a number of requirements. Despite the fact that among biomaterials an important place is occupied by metals, inorganic and carbon compounds, the priority belongs to polymers. The development of new biomaterials with improved properties significantly expands the possibilities of their practical application. Antimicrobial properties are extremely important, which prevent the occurrence of infections and increase the effectiveness of control of their pathogens [13]. There has been an increase in the number of patients suffering from wounds and burns that are difficult to treat and heal [4]
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