The significance of habitual calcium intake in the pathogenesis of peri- and early postmenopausal bone loss.

Abstract

The first hypothesis for the pathogenesis of postmenopausal osteoporosis was postulated by Albright and colleagues (1941). They suggested a cause and effect relationship between estrogen withdrawal and the occurrence of crush fractures of the vertebrae resulting from loss of bone. Since then ovarian failure has been considered to be the most important determinant of the accelerated bone loss in women during the early postmenopause, and the evidence that the adverse skeletal changes can be prevented with estrogen replacement therapy seems reasonably firm (Weiss et al.,1980; Kreiger et al.,1982; Ettinger et al.,1985).KeywordsBone Mineral DensityBone LossCalcium IntakeCalcium SupplementationOvarian FailureThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.