The significance of detection of high sensitive troponin T and creatine kinase isoenzyme in diagnosis of pediatric myocarditis

Abstract

Objective To learn the significance of detection of high sensitive troponin T and creatine kinase isoenzyme in diagnosis of pediatric myocarditis.To provide reliable laboratory diagnosis method for the disease. Methods 23 cases of pediatric myocarditis, 28 cases of viral myocarditis with capillary bronchitis and 61 cases of myocarditis with neonatal pneumonia were selected as the research objects; and 48 cases of healthy control group, 55 cases of capillary bronchitis and 49 cases of neonatal pneumonia were also selected.Blood samples were collected from all the patients and healthy controls, and the levels of high sensitive serum troponin T and creatine kinase isoenzyme were also measured. Results There was no significant difference in the detection results of high sensitive troponin T and creatine kinase isoenzyme between the healthy control group, children with capillary bronchitis and neonatal pneumonia (all P>0.05); high sensitive troponin T and creatine kinase isoenzyme detection results of myocarditis, myocarditis complicated with bronchiolitis, myocarditis complicated with neonatal pneumonia were higher than those in healthy control group, the differences were statistically significant (t=13.723, 6.628, 10.079, 9.475, 17.650, 15.364, all P<0.05). The abnormal rates of combined detection of children with myocarditis, myocarditis combined with capillary bronchitis, myocarditis combined with neonatal pneumonia were higher than those of single detection of high sensitive troponin T and single detection of creatine kinase isoenzyme (χ2=7.426, 6.310, 6.720, 4.308, 4.381, 6.900, all P<0.05). The high sensitive troponin T and creatine kinase isoenzyme in the children with the age of 1-12 months and 1-3 were lower than those with the age of<1 month, the differences were statistically significant (t=3.498, 4.043, 4.202, 4.132, all P<0.05). Conclusion The simultaneous detection of high sensitive troponin T and creatine kinase isoenzyme can be used in the diagnosis of pediatric myocarditis, with good clinical application value. Key words: High sensitive troponin T; Creatine kinase isoenzyme; Pediatric myocarditis; Capillary bronchitis; Neonatal pneumonia