Abstract
Objective To investigate the serum superoxide dismutase(SOD), malondialdehyde (MDA), and nitric oxide(NO)level in generalized anxiety disorder (GAD) patients for exploring the importance of oxidative stress in etiology of GAD. Methods 42 cases of first episode patients with GAD (GAD group) and 42 cases of health (control group) matched with age and gender were included . Serum levels of SOD, MDA , and NO were tested to analyze for a control study. Results GAD patients had significantly higher levels of SOD, MAD and NO than health controls ((858.09±137.32)×102 U/L vs (745.40±119.19) ×102 U/L; (10.92±3.42)mmol/L vs(7.52±2.32)mmol/L; (74.32±12.34) μmol/L vs(65.22±14.29) μmol/L), t=4.036, 5.368, 3.297; P=0.000, 0.000, 0.003). A positive relationship between SOD and total score of Hamilton Anxiety Scale(HAMA ), psychotic anxiety factor of HAMA, or somatic anxiety factor of HAMA was found in GAD group (r=0.331, 0.370, 0.318; P=0.029, 0.016, 0.040). The level of MAD correlated with total score or psychotic anxiety factor of HAMA(r=0.311, 0.320; P=0.042, 0.039). Conclusion It is suggested that the dysfunction of oxidative stress may play a role in pathogenesis of generalized anxiety disorder. Key words: Generalized anxiety disorder; Superoxide dismutase; Malondialdehyde; Nitric oxide
Published Version
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