Abstract
The immune responses of mice, hamsters and ferrets were measured following immunization with varying doses of either inactivated, whole or split-adsorbed subunit influenza A/Port Chalmers/1/73 virus vaccine. In all animal model systems, the adsorbed subunit virus vaccine was more immunogenic in inducing serum HI and NI antibodies than whole virus vaccine. However, complete protection, as measured by the ability of the vaccines to inhibit viral replication, was apparent in the mouse and hamster systems but not in the ferret model. The merits of each animal as a model system for determining the immunogenicity of inactivated influenza vaccines in humans was assessed. Thus, in ferrets, 1200 i.u. of adsorbed subunit vaccine induced a mean serum HI antibody titre of 1:1163, whereas an equivalent dose of whole virus vaccine induced a mean titre of 1:166. In mice and hamsters, the highest doses of both vaccines induced high serum HI antibody titres; however, in mice 100 i.u. of split adsorbed vaccine promoted a mean serum HI antibody titre of 1:264 compared to a mean titre of 1:13 induced by a similar dose of whole virus vaccine. In hamsters, 25 and 5 i.u. of split adsorbed vaccine produced 6·6- and 10-fold higher serum HI antibody titres, respectively, than whole virus vaccine.
Published Version
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