Abstract
During the 1976 National Immunization Program large scale clinical studies of A/New Jersey/76, A/Victoria/75 and B/Hong Kong influenza virus vaccines were performed. These vaccines have now been tested in mice for their ability to induce serum HI antibody and to confer resistance to challenge infection. Vaccines were compared on the basis of their hemagglutinin content, rather than their CCA titer. The results indicate that sub-unit influenza A vaccines are less antigenic than equal doses of whole virus vaccine given to non-primed mice but that the relative antigenicity of a specific manufacturer's sub-unit vaccine may vary depending on the virus strain. Influenza B vaccines were of similar antigenicity in mice, regardless of the method of manufacture. A good correlation between serum HI antibody titer and resistance to challenge infection was found for all vaccines. Comparison of the results of these mouse protection experiments and the findings from the human studies with the same vaccines indicates that only in some general areas are mouse responses an indicator of human responses.
Published Version
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