Abstract
Publisher Summary This chapter discusses the role of subthalamic mechanisms in hunger and thirst. The chapter describes experiments conducted on rats, in which it was found that rats with small electrolytic lesions in the subthalamic region were slightly hypodipsic when food was available ad libitum but drink little or no water during prolonged periods of food deprivation. This shows that the water intake of these animals may be motivated exclusively by immediate prandial needs rather than normal regulatory responses to osmotic or volumetric deficits, which are thought to initiate water intake in the intact rat. Lesions in the lateral preoptic area, rostroventral to the zona incerta have been reported to impair 2-DG feeding without affecting ad libitum intake and to abolish drinking responses to osmotic stimuli without impairing the drinking response to PG-induced hypovolemia.
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