Abstract
This chapter discusses kindling, transference phenomenon between temporal cortex and limbic structures in cats. The transference phenomenon, which is the efficient rekindling of a secondary brain site after completing the primary site kindling, is the new method to study secondary epileptogenic changes. In an experiment described in the chapter, all animals developed generalized convulsions following daily stimulation. Depending upon the brain structure of the primary site, cortical kindling (anterior, mid, and posterior sylvian gyrus) and limbic kindling (amygdaloid, hippocampal, and septal) were divided. One of the characteristic findings of the cortical kindling was the instability of the final stage of convulsions, that is, frequent regression from generalized convulsion to partial seizure. Positive transfers from the sylvian gyrus kindling to the limbic structure in some animals, and emergence of interictal discharges in the amygdala and hippocampus during cortical kindling were observed. These changes had no influence on the principal pattern of sylvian gyrus seizure development. Together with negative transference from limbic kindling to the sylvian gyrus, neural changes involving in the seizure development may be different between the cortical kindling and the limbic kindling.
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