Abstract
The role of mitochondria in aging and disease remains contentious more than 40 years after the mitochondrial free radical theory of aging was first proposed. As part of a wider cross-journal series on contemporary mitochondrial biology, Longevity & Healthspan presents a thematic series of four reviews that discuss the evidence for and against the modern incarnations of the theory, and examine the relevance of mitochondrial membrane phospholipid unsaturation and the interactions of mitochondria with sex hormones.
Highlights
The role of mitochondria in aging and disease remains contentious more than 40 years after the mitochondrial free radical theory of aging was first proposed
The free radical theory of aging has certainly done that since Harman proposed it in its general form in 1956 [1] and in a more mitochondrially-oriented form in 1972 [2]
This theory proposes that the primary cause of aging is mitochondrial production of free radicals and the mitochondrial damage that ensues
Summary
Aging: a theory based on free radical and radiation chemistry. 3. Harman D: Free-radical theory of aging. 4. Yu BP, Yang R: Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis. 5. Cadenas E, Davies KJ: Mitochondrial free radical generation, oxidative stress, and aging. 7. Beckman KB, Ames BN: The free radical theory of aging matures. 8. Sanz A, Pamplona R, Barja G: Is the mitochondrial free radical theory of aging intact? 9. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H: Trends in oxidative aging theories. Gruber J, Schaffer S, Halliwell B: The mitochondrial free radical theory of ageing–where do we stand? Perez VI, Bokov A, Van Remmen H, Mele J, Ran Q, Ikeno Y, Richardson A: Is the oxidative stress theory of aging dead?
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