The role of insulin-like growth factor in Acrochordon Etiopathology

Hanife Gündoğdu Köseoğlu,Ramazan Sarı,Sadıka Halide Akbaş,Cumhur İbrahim Başsorgun,Burçin Cansu Bozca,Ayşe Akman Karakaş

doi:10.1186/s12895-020-00111-0

Hanife Gündoğdu Köseoğlu, Ramazan Sarı + Show 4 more

Open Access

https://doi.org/10.1186/s12895-020-00111-0

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Journal: BMC Dermatology	Publication Date: Nov 3, 2020
Citations: 7	License type: open-access

Affiliation: Akdeniz University Hospital, Akdeniz University

Abstract

BackgroundThere are reports that acrochordon (skin tag), the most common fibroepithelial tumor of the skin, may be associated with metabolic syndrome components, particularly insulin metabolism disorders. However, to the best of our knowledge, there is no study examining its association with insulin resistance and tissue levels of insulin-like growth factor 1 receptor (IGF-1R) and insulin-like growth factor 2 receptor (IGF-2R).MethodsThirty patients with at least one acrochordon in their body who had no known history of diabetes mellitus and a control group comprised 30 individuals who had no acrochordon or no known history of diabetes mellitus were included. The tissue expression of IGF-1R and IGF-2R were investigated via immunohistochemical assessment in both groups.ResultsIn the group with acrochordon, IGF-1R and IGF-2R expression was found to be significantly higher compared to the control group (p < 0,01). Using logistic regression analysis, an increase in serum insulin, serum IGF-1 and HOMA-IR levels was found to be associated with the expression levels of IGF-1R and IGF-2R.ConclusionThese findings support the view that insulin metabolism disorders should be evaluated in patients with acrochordon. Our study indicates that IGF receptors may have an effect on acrochordon pathogenesis and that acrochordon etiology and related conditions can be clarified by detection of parameters that influence receptor levels.

Highlights

There are reports that acrochordon, the most common fibroepithelial tumor of the skin, may be associated with metabolic syndrome components, insulin metabolism disorders
The intensity of Insulin-like growth factor (IGF)-1R staining was positively correlated with serum IGF-1 level and Body mass index (BMI). These results indicate that an increase in BMI may directly be associated with the presence of IGF receptor and intensity of receptor staining in tissue
High insulin levels may directly affect the presence and intensity of IGF receptors, leading to the development of acrochordons. The presence of both Insulin-like growth factor receptor–1 (IGF–1R) and Insulin-like growth factor–2 (IGF–2R) staining were found to be significantly more frequent in normoglycemic patients with acrochordon compared to controls. These results suggest that the levels of IGF receptors may play a role in the pathogenesis of acrochordon, regardless of impairment in glucose metabolism

Summary

Introduction

There are reports that acrochordon (skin tag), the most common fibroepithelial tumor of the skin, may be associated with metabolic syndrome components, insulin metabolism disorders. To the best of our knowledge, there is no study examining its association with insulin resistance and tissue levels of insulin-like growth factor 1 receptor (IGF-1R) and insulin-like growth factor 2 receptor (IGF-2R). Acrochordons are 1 mm to 1 cm (rarely giant sized) papules that may or may not have stems. Their color ranges from skin color to dark brown [1]. It is believed that the task of the IGF–2R receptor is to decrease the serum. Köseoğlu et al BMC Dermatology (2020) 20:14 level of IGF-2 which is the only ligand of this receptor. When the level of IGF–2 decreases in the serum, it binds to IGF-1R to a lesser extent. IGF-2R is thought to suppress tumor growth and proliferation by indirectly suppressing IGF-1R activation [8]

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