The role of histone deacetylase enzymes in the pathogenesis of bronchial asthma

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Airway inflammation,airway remodeling and airway hyperresponsiveness are major aspects of bronchial asthma(asthma) pathology.Gene modification such as acetylation plays an important role in the progress.The core histone acetylation activity is high in the active region of gene transcription, while at the non-active region,a low degree of acetylation[1].As a dynamic reversible progress,if the balance is destroyed,it will lead to the gene transcription disorders,causing the abnormal gene expression. In the pathogenesis of asthma,histone acetylation and deacetylation modification changed differently, which participated in the formation of airway inflammation,airway remodeling and hyperresponsiveness. In recent years,a large number of experiments have confirmed that histone deacetylase inhibitors have anti-inflammatory,antioxidant and anti-proliferative effects.According to study the differences of histone deacetylation in normal and abnormal lung tissue and the effects of histone deacetylase inhibitors to the lung structure cells and inflammatory cells,we speculated that histone deacetylase inhibitors may alleviate asthma airway inflammation,airway remodeling and airway hyperresponsiveness[2]. Key words: Histone acetylase; Histone deacetylase; Histone deacetylase inhibitors; Asthma; Airway inflammation; Airway remodeling; Airway hyperresponsiveness