THE ROLE OF GENETIC FACTORS IN REPRODUCTIVE DYSFUNCTION IN ADOLESCENTS WITH VARICOCELE

Abstract

In the pathogenesis of male infertility, up to 30% of cases can be attributed to the role of genetic factors and cause both minor changes in spermatogenesis and absolute dysfunction of the gonads. With varicocele under conditions of testicular ischemia and hypoxia, the expression of various genes responsible for spermatogenesis can be modified. Target. To assess the contribution of genetic factors to the risk of reproductive dysfunction in adolescents with varicocele. Materials and methods. Adolescents with varicocele underwent karyotype analysis, study of deletions of the AZF and CFTR gene loci, and spermogram evaluation. Results. When evaluating the karyotype in adolescents with varicocele, shortening of the long arm of the Y chromosome was detected in 1 case (1%), a study of the AZF locus in three people from the main group (3%) revealed a deletion of sY1291, one person (1%) was diagnosed with a deletion in CFTR gene — Nmdel F508. In the study of spermogram, normozoospermia (52%) was most often diagnosed in adolescents with varicocele, and asthenozoospermia (24%) was diagnosed as pathological changes. Conclusions. 1. The frequency of detection of genetic factors of infertility in adolescents with varicocele does not exceed 5%. 2. The identified genetic variants in the groups of adolescents examined did not lead to impaired spermatogenesis, which allows us to consider the contribution of genetic causes to reproductive dysfunction in varicocele as insignificant.