Abstract
The aim of study was to conduct the comparative regenerative, anti-inflammatory and antimicrobial properties of tetraderm and triderm in experiment. Materials and methods. Experiment was performed on 85 white male rats. Investigational medicines were applied 2 times a day at a dose of 0.01 g/cm2. The pharmaceuticals were applied in prophylactic scheme (2 and 1 hours before the induction of inflammation) and therapeutic scheme (1 hour after the induction of inflammation) for 7 days for the treatment of carrageenan-induced inflammation. Tetraderm and triderm were applied 24 hours after the thermal burn to the affected area of the skin during 21 days. Treatment of linear wounds was performed for 7 days 24 hours after surgery. The antibacterial and antifungal effects of drugs were evaluated in vitro. Results. Tetraderm reduced the limb edema by more than 50% in a prophylactic scheme compared with triderm. The anti-inflammatory effect of pharmaceuticals was comparable. Tetraderm shown pronounced regenerative ability and reduced the burn area by 1,5 times compared with triderm. The stimulating healing effect of tetraderm on the skin wound of the linear skin wound model was similar to that of triderm. The antimicrobial activity of the tetraderm and triderm was comparable. Tetraderm showed a fungicidal effect against yeast and mold fungi. Triderm had only a fungistatic effect against yeast С. albicans and suppressed of the growth of A. Niger. Conclusions. The regenerative and anti-inflammatory effect of tetraderm with antibacterial activity shows auspicious conditions for healing wounds and burns. The regenerative, antibacterial and fungicidal effects of tetraderm are slightly superior to the triderm effect.
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