The role of D-dimer in detection and diagnosis of mycoplasma pneumonia

Abstract

Objective To investigate the role of D-dimer in the diagnosis and evaluation of mycoplasma pneumonia. Methods The positive rate and concentration of D-dimer in mycoplasma pneumonia, bacterial pneumonia, viral pneumonia and healthy controls were detected and compared.The positive rate and concentration of D-dimer in patients with systemic inflammatory response syndrome (SIRS) and without SIRS were observed.Changes of D-dimer concentration in patients with mycoplasma pneumonia before and 2 weeks after treatment were observed. Results Compared with bacterial pneumonia group (16.7%), the viral pneumonia group (20.0%) and healthy control group (0.0%), the positive rate of D-dimer in mycoplasma pneumonia group (41.6%) was significantly higher (χ2=5.625, 4.158, 17.308, all P<0.05). The positive rate of mycoplasma pneumonia group with SIRS (64.0%) was significantly higher than that in other groups (χ2=17.308, P<0.05). The D-dimer levels of the mycoplasma pneumonia group [(324.4±125.3)μg/L], bacterial pneumonia group[(282.3±95.4)μg/L ] and viral pneumonia group[(293.1±92.3)μg/L ]were significantly higher than that in the healthy controls[(72.9±22.4)μg/L ](t=10.878, 11.704, 12.698, all P<0.05). The concentration of D-dimer[(381.4±129.4)μg/L] in the mycoplasma pneumonia group with SIRS was significantly higher than that in the other groups(t=2.668, P<0.05). Compared with before treatment, the concentration of D-dimer after treatment in the two groups was significantly lower[(129.3±65.3)μg/L, (89.7±28.6)μg/L](t=2.582, P<0.05). Conclusion The level of D-dimer in children with mycoplasma pneumonia was significantly increased, and the severity of the disease could be reflected. Key words: Mycoplasma pneumonia; Diagnosis