Abstract
Purpose: Thrombotic complications have been reported in up to 30% of patients admitted to ICU for COVID-19. However, data concerning hemodialysis access failure in subjects with COVID-19 is limited. This study aimed to investigate the frequency of hemodialysis access failure and its determinants, especially with respect to COVID-19 status.
 Patients and methods: This multi-center cross-sectional study was conducted among subjects undergoing permanent hemodialysis. Patients were divided into two groups, those with and without access failure. The primary outcome measures of the study were differences in patient characteristics, laboratory measurements and COVID-19 positivity between the two groups. The secondary outcome measure was defined as the identification of factors independently associated with hemodialysis access failure.
 Results: Hemodialysis access failure occurred in 26 (12.2%) patients. When those with access failure were compared to those without failure, type 2 diabetes (76.9% vs. 50%, p=0.018), hypotension during dialysis (88.5 vs. 58.1%, p=0.006) and COVID-19 positivity (73.1% vs. 15.1%, p
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