The risk factors and bacterial susceptibility analysis of in severe acute pancreatitis complicated with intra-abdominal infections

Abstract

Objective The aim of the study was to find out the risk factors of the severe acute pancreatitis(SAP)complicated with intra-abdominal infections according to the retrospective analysis of the clinical data of 280 patients with SAP in Quanzhou First Hospital of Fujian Medical University,and to analyze the bacterial spectrum,drug sensitivity in patients with intra-abdominal infections for clinical diagnosis and treatment. Methods Collected the clinical data of 280 patients,the relationship between the factors which have significant difference in patients complicated with intra-abdominal infections and no intra-abdominal infections patients was explored according to the Logistic regression analysis,and analysized the predisposing factor of SAP complicated with the intra-abdominal infections.The ascite specimens and the necrotic tissues of SAP patients complicated with the intra-abdominal infections were harvested for bacterial culture and drug sensitivity analysis. Results The Multiple organ dysfunction syndrome,seroperitoneum,Ca and intestinal dysfunction were the risk factors of SAP with the intra-abdominal infections,the main pathogenic bacteria was gram-negative bacteria.The top two gram-negative bacteria were Escherichia coli,pseudomonas aeruginosa,and the top two gram-positive bacterium were enterococcus,staphylococcus aureus.They were generally not sensitive to common antibiotics. Conclusion The early therapy of SAP complicated with the intra-abdominal infections should be basd on the risk factors,bacterial spectrum,and drug sensitivity,in order to increase the clinical therapeutic effect. Key words: Severe acute pancreatitis; Intra-abdominal infections; Logistic regression analysis; Bacterial susceptibility testing