The research of effect of Low-dose simvastatin on vascular endothelial function in patients with hypertensives and its safety

Abstract

Objective To explore the low-dose simvastatin (5 mg)on vascular endothelial function in hypertensives and safety of low-dose.Methods 204 hypertensives were randomly divided into 3 groups: conventional control group( conventional antihypertensive treatment alone without oral simvastatin),5 mg group (simvastatin 5 mg/d),20 mg group( simvastatin 20 mg/d)respectively 68 cases were treated for 12 weeks,and blood lipid,hepatic and rena function,muscle enzymes,blood cells were detected before treatment and two weeks after treatment,during the the patients with adverse drug reaction of simvastatin will withdraw from the study,Before and after treatment brachial artery endothelial FMD ( flow-mediated dilation) and NMD ( nitroglycerin-mediated dilation) were detected using color Doppler ultrasound,the changes in level of lipid of 3 groups were observed before and after treatment and changes in endothelial function and lipid levels in each group before and after treatment and incidence of adverse reactions of simvastatin each group were compared.Results ①The incidence of adverse drug reactions of simvastatin in 5 mg and 20 mg group Group were respectively 4.41%,25% and the incidence of adverse drug reactions of simvastatin in 5 ng was was significantly lower than in 20 mg group ( P ＜ 0.05 ).②The level of TC,LDL-C after treatment in 20 mg group than before treatment decreased significantly(P ＜0.05);FMD in 5 mg and 20 mg groups were significantly improved pre-treatment(P ＜0.05),Changes in the value of FMD were no difference in 5 mg and 20 mg groups( P ＞ 0.05).Conclusion The incidence of adverse drug reactions in Low-dose simvastatin is fewer,both low-dose and conventional-dose simvastatin can significantly improve vascular endothelial function in hypertensives.These patients which need long-term use of statins and whose lipid levels are not too high or low may use low doses statins drugs,which could play a role improving vascular endothelial function but not a role of regulation of lipid levels and reduce incidence of adverse cardiovascular and cerebrovascular events,ultimately reduce the complications of hypertension. Key words: Low-dose simvastatin; Hypertension; Vascular endothelial function; Security; Serum lipid