Abstract
Aim: Imidacloprid (IMI) is a systemic insecticide which produces neurotoxicity through binding to acetylcholine receptor. Toxic effects of IMI are sperm deformity, testis Tubular degeneration, and developmental retardation in mammalian fetus. We aimed to study the toxicity of IMI toward ovary and mRNA of DAX1 expression that is associated ovarian follicular growth. Methods: 90 Pregnant Wistar rats were randomly divided into control, sham and IMI group. IMI and sham groups received 10 mg/kg BW IMI and DMSO as solvent of IMI, respectively. 1, 14 and 55-day-old Rats were anesthetized and their Blood and ovaries were removed to determine serological and histomorphometrical change. RT-PCR was also carried out to evaluate the expression of DAX1 gene. Results: Follicles diameters and corpus luteum numbers, estradiol and progesterone levels and main parameters of pregnancy significantly decreased in IMI group compare with control group. RT-PCR results showed down-regulation of DAX1 gene.
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