Abstract
Many biological processes are affected by electromagnetic fields. Effect of electromagnetic field on proliferation, cell division, wound healing and gene expression were examined. Angiogenesis, new blood vessel formation, which is required for embryonic development and many physiological events, plays a crucial role in the pathobiology of tumors and researches show angiogenesis inhibition could be an effective therapeutic strategy for patients with cancer. In this research, effects of low-frequency electromagnetic field on VEGF-A, VEGFR-2 and MMP gene expression as potent biomarkers of angiogenesis was investigated in human breast cancer cells. MCF-7 cells were grown in RPMI 1640 medium supplemented with 10
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