The relationship between serum sialic acid, high-sensitivity C-reactive protein and prehypertension and their clinical significance

Abstract

Objective To explore the relationship between serum sialic acid(SA), high-sensitivity C-reactive protein(hs-CRP) and prehypertension and their clinical significance. Methods According to the blood pressure range, 160 residents who received physical examination were divided into three groups: normal group(40 cases), prehypertension group (60 cases) and hypertension group (60 cases). The blood pressure, height and weight were measured in all subjects, and the serum levels of SA, hs-CRP, serum total cholesterol(TC), low density lipoprotein(LDL), high density lipoprotein(HDL), triacylglycerol(TG) and fasting plasma glucose(FBG) were detected on the same day.Multiple linear regression was used to investigate the relationship between serum SA and hs-CRP levels and systolic blood pressure(SBP) and diastolic blood pressure(DBP). Results The levels of DBP, SBP, body mass index(BMI), SA, hs-CRP, TC, LDL, HDL and FBG among the three groups were statistically significant(F=1 102.039, 2 690.642, 9.163, 116.511, 103.634, 5.431, 4.267, 67.352, 4.236, all P 0.05). Multiple linear regression showed that the levels of BMI, SA, hs-CRP and FBG were positively correlated with SBP(r=3.66, 2.61, 3.24, 2.39, all P<0.05), and the levels of BMI, SA, hs-CRP and LDL were positively correlated with DBP(r=2.20, 2.34, 3.48, 2.28, P all<0.05). Conclusion The levels of serum SA and hs-CRP are positively correlated with blood pressure, which can be used as assessment criteria for prehypertension. Key words: Prehypertension; Sialic acid; C-reactive protein