The relationship between dyslipidemia and colorectal cancer

Abstract

Objective To explore the relationship between dyslipidemia and colorectal cancer. Methods The levels of total cholesterol(TC),triglyceride(TG), 1ow density lipoprotein- cholesterol(LDL- C)and high density lipoprotein- cholesterol(HDL- C)of 182 patients with colorectal cancer and 86 controls were tested. The serum lipids levels between the colorectal cancer group and control group, colorectal cancer with different location,different gender were compared. Results The level of TCin the colorectal cancer group[(5.51±0.76)mmol/L]was significantly higher than that of the control group[(4.84 ±0.53)mmol/L](t= 2.41,P 0.05).TClevel in the male colorectal cancer group[(5.96±0.87)mmol/L]was significantly higher than that of the female colorectal cancer group[(5.26±0.74)mmol/L](t= 2.10,P<0.05). The level of TC in the distal colon and rectal cancer group was(6.07± 0.78)mmol/L,which was significantly higher than(5.14±0.56)mmol/L of the proximal colon cancer group(t= 3.24,P<0.05);The level of HDL- C in the distal colon and rectal cancer group was(0.75±0.26)mmol/L,which was significantly lower than(1.07±0.19)mmol/L of the proximal colon cancer group(t=- 3.20,P< 0.05). Conclusion TC was positively correlated with colorectal cancer,and HDL-C was negatively correlated with colorectal cancer. Key words: Colorectal cancer; Total cholesterol; Triglyceride; Low density lipoprotein-cholesterol; High density lipoprotein-cholesterol