Abstract
The red blood cell (RBC) is an essential player in the delivery of oxygen. As such, RBCs rely on an intricate network of membranous carbohydrate and protein antigens which help to maintain their deformability as they navigate complex vascular structures and allow for cell–cell interactions. However, such antigens can occasionally become targets of a host's immune system, leading to the development of an antibody response with a subsequent clearance of the targeted cell. The aim of this article is to review the pathophysiology and classification of the various conditions which can lead to the development of an immunologic response to RBC antigens. This article will also detail diagnostic approaches and treatment options for scenarios when the RBC is targeted for destruction by the immune system.
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