Abstract
Experimental tools that are designed to perturb biological functions are often used to understand how cells change over time. However, in two recent papers, Segall-Shapiro etal. (2018; in Nature Biotechnology) and Rullan etal. (2018; in this issue of Molecular Cell) present tools engineered to keep cells the same. Both toolsachieve perfect adaptation, that is, the ability to hold a value, in this case gene expression, constant over time despite disruptions and disturbances. Together, these papers highlight how influential dynamics can be when shaping biological functions, even when the goal is to stay constant.
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