Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes

Abstract

articleGlycosaminoglycans: molecular properties, protein interactions, and role in physiological processesR. L. Jackson, S. J. Busch, and A. D. CardinR. L. JacksonMarion Merrell Dow Research Institute, Cincinnati, Ohio., S. J. BuschMarion Merrell Dow Research Institute, Cincinnati, Ohio., and A. D. CardinMarion Merrell Dow Research Institute, Cincinnati, Ohio.Published Online:01 Apr 1991https://doi.org/10.1152/physrev.1991.71.2.481MoreSectionsPDF (21 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByGlycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degenerationMatrix Biology, Vol. 71-72Morphology of the vaginal complex in the white-eared opossum ( Didelphis albiventris) : Gross anatomy and light microscopy7 September 2018 | Anatomia, Histologia, Embryologia, Vol. 76Composition and structure of glycosaminoglycans in DBS from 2-3-day-old newborns for the diagnosis of mucopolysaccharidosisAnalytical Biochemistry, Vol. 557IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategiesBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1860, No. 9Targeting Heparan Sulfate Proteoglycans as a Novel Therapeutic Strategy for MucopolysaccharidosesMolecular Therapy - Methods & Clinical Development, Vol. 10Utilization of Host-Derived Glycans by Intestinal Lactobacillus and Bifidobacterium Species17 August 2018 | Frontiers in Microbiology, Vol. 9Purification, characterization of Chondroitinase ABC from Sphingomonas paucimobilis and in vitro cardiocytoprotection of the enzymatically degraded CS-AInternational Journal of Biological Macromolecules, Vol. 115Revisiting glycoside hydrolase family 20 β- N -acetyl- d -hexosaminidases: Crystal structures, physiological substrates and specific inhibitorsBiotechnology Advances, Vol. 36, No. 4The smaller heparin fragments bind non-specifically through the IAPP sequence: An in silico studyInternational Journal of Biological Macromolecules, Vol. 113Preventive effect on endothelial surface layer damage of Fusu agent in LPS-induced acute lung injury in rats14 June 2018 | Molecular and Cellular Biochemistry, Vol. 369Cytotoxic and glycosaminoglycan priming activities of novel 4-anilinequinazoline β-D-xylosidesCarbohydrate Research, Vol. 463Injectable silk fibroin hydrogels functionalized with microspheres as adult stem cells-carrier systemsInternational Journal of Biological Macromolecules, Vol. 108The interstitium conducts extrarenal storage of sodium and represents a third compartment essential for extracellular volume and blood pressure homeostasis20 December 2017 | Acta Physiologica, Vol. 222, No. 3One-pot analysis of sulfated glycosaminoglycans5 December 2017 | Glycoconjugate Journal, Vol. 35, No. 1The effect of interleukin-8 truncations on its interactions with glycosaminoglycans27 January 2018 | Biopolymers, Vol. 356Bioactive Properties and Biotechnological Production of Human Milk OligosaccharidesHyaluronan size alters chondrogenesis of adipose-derived stem cells via the CD44/ERK/SOX-9 pathwayActa Biomaterialia, Vol. 66Differential calixarene receptors create patterns that discriminate glycosaminoglycans1 January 2018 | Organic Chemistry Frontiers, Vol. 5, No. 18Current aspects of the role of glycosaminoglycans of the extracellular matrix in the development of generalized periodontitis and the course of repair processes22 December 2017 | Proceedings of the Shevchenko Scientific Society Medical sciences, Vol. 50, No. 2The Borrelia burgdorferi Glycosaminoglycan Binding Protein Bgp in the B31 Strain Is Not Essential for Infectivity despite Facilitating Adherence and Tissue Colonization22 January 2018 | Infection and Immunity, Vol. 86, No. 2Glycosaminoglycans (GAGs) and GAG mimetics regulate the behavior of stem cell differentiationColloids and Surfaces B: Biointerfaces, Vol. 150Total and single species of uronic acid-bearing glycosaminoglycans in urine of newborns of 2–3 days of age for early diagnosis applicationClinica Chimica Acta, Vol. 463Habitat and taxon as driving forces of carbohydrate catabolism in marine heterotrophic bacteria: example of the model algae-associated bacterium Zobellia galactanivorans Dsij T13 November 2016 | Environmental Microbiology, Vol. 18, No. 12Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer1 June 2016 | Oncology Letters, Vol. 12, No. 1The role of endothelial mechanosensitive genes in atherosclerosis and omics approachesArchives of Biochemistry and Biophysics, Vol. 591Stimulation of Superficial Zone Protein/Lubricin/PRG4 by Transforming Growth Factor-β in Superficial Zone Articular Chondrocytes and Modulation by GlycosaminoglycansTissue Engineering Part A, Vol. 21, No. 13-14Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma19 January 2015 | Molecular and Clinical Oncology, Vol. 3, No. 3Physical Biology in Cancer. 3. 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