The protective effects of mild hypothermia on cerebral and levels of serum levels of anti-brain antibodies after severe traumatic brain injury

Abstract

Objective To study the protective effects of mild hypothermia on cerebral and levels of serum levels of anti- brain antibodies after severe traumatic brain injury. Methods Severe traumatic brain injury were selected as theⅠgroup(n= 60), also select healthy as the Ⅱ group(n= 30), theⅠgroup was divided into group A(n= 30)and group B(n= 30)according to a random number table.The patients of group A was given hypothermia and the patients of group B were treated with temperature treatment, the levels of anti- brain antibodies in serum of each group were determined in ELISA assay, changes in cerebral blood flow before and after treatment of group A and group B were observed in Doppler, and observed Glasgow Outcome Score(GOS)of group A and group B. Results The level of anti- brain antibodies in serum of theⅠgroup was(0.59±0.02)U/mL significantly higher than that ofⅡgroup(0.38 ±0.01)U/mL,the difference was statistically significant(t= 9.192,P= 0.029);the level of anti- brain antibodies in serum after treatment of group A was(1.58±0.03)U/ml significantly lower than that of group B(1.82±0.04)U/ mL, the difference was statistically significant(t= 10.042,P= 0.019); the average flow velocity,pulse index and GCS score after treatment of group A were(54.20±0.23)cm/s,(0.51±0.02),(10.03±1.03)points significantly better than those of group B[(40.03±0.04)cm/s,(0.72±0.02),(8.12±0.02)points], the difference was statistically significant(t= 9.892,10.041,9.189,P= 0.021,0.018,0.026). Conclusion The levels of anti-brain antibodies in serum can significantly increase after severe traumatic brain injury, Hypothermia can reduce the serum levels of anti-brain antibodies, can increase cerebral blood flow. Key words: Craniocerebral trauma; Anti-brain antibodies; Hypothermia