Abstract
Objective To determine the effect of dexmedetomidine in elderly.hypertension patients undergoing hip replacement surgery.Methods Thirty patients with hypertension of Ⅱ degree aged ＞ 65yr undergoing hip replacement surgery were randomly divided into dexmedetomidine group(D) and control group(C) with 15 cases each.Anesthesia induction and maintenance were same in two groups.In group D,dexmedetomidine Was administered intravenously at 0.7 μg/(kg·h)after a bolus infusion at 1μg/(kg·h)for 10 min.Changes of HR、SBP、DBP were monitored before anesthesia,after induction,intubation and extubation,The changes in ST segment were recorded before anesthesia,after intubation and immediately after extubation.Results HR、SBP、DBP decreased significantly after induction compared with that of before anesthesia in two groups(P＜0.05,P＜0.01)while group D were lower than that of group C after intubation and immediately after extubation.The cases of ST segment showing myocardial injury were significantly differences between group D and group C(5 VS 1)(P＜0.05).Conclusion Dexmedetomidine intravenously could attenuate the degree of myocardial damage in elderly hypertension patients undergoing hip replacement surgery. Key words: Dexmedetomidine; Hypertension; Myocardial protection
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
