Abstract
BackgroundUrothelial Carcinoma Associated 1 (UCA1) was an originally identified lncRNA in bladder cancer. Previous studies have reported that UCA1 played a significant role in various types of cancer. This study aimed to clarify the prognostic value of UCA1 in digestive system cancers.ResultsThe meta-analysis of 15 studies were included, comprising 1441 patients with digestive system cancers. The pooled results of 14 studies indicated that high expression of UCA1 was significantly associated with poorer OS in patients with digestive system cancers (HR: 1.89, 95 % CI: 1.52–2.26). In addition, UCA1 could be as an independent prognostic factor for predicting OS of patients (HR: 1.85, 95 % CI: 1.45–2.25). The pooled results of 3 studies indicated a significant association between UCA1 and DFS in patients with digestive system cancers (HR = 2.50; 95 % CI = 1.30–3.69). Statistical significance was also observed in subgroup meta-analysis. Furthermore, the clinicopathological values of UCA1 were discussed in esophageal cancer, colorectal cancer and pancreatic cancer.Materials and methodsA comprehensive retrieval was performed to search studies evaluating the prognostic value of UCA1 in digestive system cancers. Many databases were involved, including PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure and Wanfang database. Quantitative meta-analysis was performed with standard statistical methods and the prognostic significance of UCA1 in digestive system cancers was qualified.ConclusionsElevated level of UCA1 indicated the poor clinical outcome for patients with digestive system cancers. It may serve as a new biomarker related to prognosis in digestive system cancers.
Highlights
Cancer is becoming the leading cause of death in both developed and developing countries [1]
Elevated level of Urothelial Carcinoma Associated 1 (UCA1) indicated the poor clinical outcome for patients with digestive system cancers. It may serve as a new biomarker related to prognosis in digestive system cancers
Six studies were about colorectal cancer [16, 19, 21, 24, 27], three studies were about gastric cancer [22, 25], two studies were about pancreatic cancer [26, 28], two studies were about hepatocellular carcinoma [20, 23], two studies were about esophageal carcinoma [17, 29]
Summary
Cancer is becoming the leading cause of death in both developed and developing countries [1]. Digestive system malignant tumors occupy most of the all-cancer incidence and mortality, with 3.4 million new diagnosed cases and 1.5 million deaths each year [2]. The prognosis of patients with digestive system malignancies were unfavorable. Effective and accessible clinical biomarkers were urgently required for the prognosis prediction of patients with digestive system malignant tumors, since there was still no specific and accepted biomarker for this kind tumors. LncRNAs www.impactjournals.com/oncotarget account for more than 80% of the entire genome transcripts [3]. LncRNAs were always considered as transcriptions of “noise” or clonal artifacts [4]. Urothelial Carcinoma Associated 1 (UCA1) was an originally identified lncRNA in bladder cancer. This study aimed to clarify the prognostic value of UCA1 in digestive system cancers
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