The Probiotic BIOHM Improves Nutrient Absorption by Disrupting Gastrointestinal Biofilms

Ghannoum M,Mccormick Ts,Isham N,Retuerto M,Ghannoum A,Hager C

doi:10.35248/2329-8901.7.2.213

Abstract

The Probiotic BIOHM Improves Nutrient Absorption by Disrupting Gastrointestinal Biofilms

Highlights

Technological advancements that have improved identification of the microbial makeup of the human gastrointestinal (GI) tract, as well as the biochemistry of digestion, have increased our understanding of the mechanisms of nutrient absorption
Treatment with the probiotic led to a significant increase in penetration of casein through the epithelial cell monolayer in the absence of biofilms (p
It stands to reason that any obstruction of the mucosal layer of the small intestine may impede the vital function of the enterocytes in nutrient absorption

Summary

Introduction

Technological advancements that have improved identification of the microbial makeup of the human gastrointestinal (GI) tract, as well as the biochemistry of digestion, have increased our understanding of the mechanisms of nutrient absorption. Characterization of the action of both host and microbial enzymes has served to inform the absorption routes of nutrients through the intestine. The interaction of gut microorganisms with the intestines begins at the mucosal-associated layer that covers the epithelium. This layer, consisting of enterocytes and mucin secreted by goblet cells, provides a habitat for beneficial gut flora [5]. The microbial communities residing in our gut (microbiome) influence various functional activities including nutrient absorption, protection of mucosal surfaces, and structure and function of the gut [6]. Host and microbial enzymes within this layer are responsible for breaking down ingested food into micronutrients that can be absorbed through the intestinal wall. Using a mouse model we showed that these three pathogenic organisms worked together

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Discussion

Conclusion