The Potential role of Eugenol and Ocimum sanctum extract on female rats: a focus on infertility efficacy

Abstract

Objectives The aim of the present study was to evaluate the infertility effect of Eug and OS extract administrations in female albino rats.
 Methods Healthy female albino rats are provided with EUG (99% pure) with a dose of 0.4 ml/ day/ rat and OS Linn. Leaf extract with a dose of 500 mg/kg body weight/ day/ rat orally for 20 days. The control group received saline (vehicle). On day 20 of gestation, maternal and foetal, Antifertility and Antiimplantation, ovarian follicular kinetics and Estrogenic activity parameters. ANOVA Analysis One-way with Dunnett comparison tests used to analyze data. Ocimum Sanctum also gets an antifertility effect. 
 Results Oral administration of the extract from days 1 to 19 of gestation showed a reduction (p<0.05) in the number of corpora lutea of pregnancy and number of live fetuses. The foetal and placental weights were also significantly (P < 0.05) decreased in Eug and OS extract compared with the control. The results revealed that Antiimplantation activity were 87.17% and 79.48% in Eug and OS extract administration. Antifertility activity was 83.33 % in in Eug and OS extract administration.
 Conclusion The results of this study concluded the evidence for the antifertility activity of the administration of Eug and OS extract in female rats. Administration can induce the effects of inhibition on reproductive function in female albino rats.