The Possible Effects of Green Coffee Bean Extract on Progression of Experimental Diabetes in Different Organs; A Review Article

Doaa Abdel Mohsen,Ahmed Abdemoneim,Ahmed Akabawy,Hatem Amin

doi:10.21608/aprh.2021.77827.1133

Doaa Abdel Mohsen, Ahmed Abdemoneim + Show 2 more

Open Access

https://doi.org/10.21608/aprh.2021.77827.1133

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Abstract

Green coffee bean water extract consumption has been stated to have a contrary association with type 2 diabetes and metabolic syndrome. Chlorogenic acid (CGA), an important biologically active dietary polyphenol, is produced by certain plant species and is a major component of coffee. Reduction in the risk of a variety of diseases following CGA consumption has been mentioned in recent basic and clinical research studies. This systematic review discusses in vivo animal and human studies of the physiological and biochemical effects of CGA on biomarkers of diabetic complication and the possible alterations produced by the administration of different doses of green coffee on biomarkers related to renal, testicular, and neurological antioxidant systems.

Highlights

Diabetes mellitus (DM) is a chronic disease with a wide range of physiological complications and a high prevalence.[1]
AlAmri, Albeltagy et al reported that an increase in kidney weight and kidney function parameters levels caused by diabetic model reversed by green coffee bean water extract (GCWE) administration
A previous study confirmed that the increased production of LPO and decreased content of GSH, SOD, GR, and GPx were obviously restored by the administration of GCWE, suggesting a clear antioxidant activity that was in line with those demonstrated in several studies 34, 35

Summary

Introduction

Diabetes mellitus (DM) is a chronic disease with a wide range of physiological complications and a high prevalence.[1]. AlAmri, Albeltagy et al reported that an increase in kidney weight and kidney function parameters levels caused by diabetic model reversed by green coffee bean water extract (GCWE) administration. Green coffee and metformin treatments exert anti-apoptotic activity through upregulating Bcl-2 and down-regulating Bax and Casp[3] as compared to the diabetic group.

Results

Conclusion