The optimal dose of sufentanil combined with ketamine for postoperative patient-controlled intravenous analgesia

Abstract

Objective To observe the effect of gynecologic surgery patient-controlled intravenous analgesia (PCIA) with different-dose sufentanil combined with ketamine for obtaining a better medicine compatibility. Methods Ninety patients, ASA I～II ,30～50 years old,scheduled for hysterectomy under general anesthesia,were randomly divided into three groups;A,B and C;30 adults were included in each group. (sufentanil 1.5μg·kg~(-1) + ketamine 4mg·kg~(-1))/100ml, ( sufentanil 2.0μg·kg~(-1) + ketamine 4mg·kg~(-1))/100ml, ( sufentanil 2.5μg·kg~(-1)+ ketamine 4mg·kg~(-1))/100ml,was used in A,B,C group respectively. Tropisetron 4mg was added in every patient. VAS, sedative scores,respiratory depression,nausea and vomiting,delire,dizzy and pruritus were recorded at the time points of 4,12,24 and 48h after operation. Results VAS scores in group A was significantly higher than those in group B and group C at all three time points (P <0. 05) , while SS in group C was significantly higher than those in group A and group B at all three time points(P <0.05). Nausea and vomiting in group C was significantly more than that in group A and B(P<0.05),and there were no significant difference in the other side effects among three groups. Con elusion Patient-controlled intravenous analgesia( PCIA) with sufentanil 2.0μg·kg~(-1) + ketamine 4mg·kg~(-1)/ 100ml is a better medicine compatibility in gynecological postoperative patients, it can provide better post-operative analgesia,also can lower adverse effect. Key words: Analgesia, patient controlled; Intravenous; Sufentanil; Ketamine