The Opioid Effects On The Cardiac Markers And Left Ventricular Contractility In Acute Myocardial Infarction Patients

Abstract

Background: Coronary artery disease is one of the most expensive diseases in the world and one of the most common causes of mortality in Iran and Lorestan state. The association between this disease and its risk factors like smoking was established. According to non medical consumption of opium in many parts of our state, we decided to perform a research in order to evaluate the opioid effects on myocardial infarction (MI) extension. Material & methods: In this descriptive analytical study, we assessed 60 patients with MI admitted in the CCU ward of Imam Khomeini Hospital. The diagnosis of MI was based on their medical history, ECG changes and cardiac enzymes approved by the same cardiologist. Then the consumption of opioid by the patients was evaluated by a questionnaire. According to opioid consumption the patients were divided into two groups. The peak amount of the CPK, CKmb and LDH enzymes and ejection fraction were recorded into two groups during their hospitalizations. Results: The mean peak of CPK and CKmb in the user opium group and in the nonuser were 1075, 152 and 906, 102 respectively. The mean peak of LDH in the users and nonusers were reported 1400 and 1029 respectively. There are significant differences between the measured enzymes between the two groups (P=0.001). Conclusions: According to the effects of opioid on the cardiac enzymes and probably on the MI extension, opioid consumption could be preventative for MI complications.