The neuroprotective effect of magnesium sulfate in treatment of patients with acute cerebral ischemic stroke

Abstract

Objective To explore the neuroprotective effect of magnesium sulfate in tretment of patients with cerebral ischemic stroke. Methods 40 patients with cerebral ischemic stroke were selected and randomly divided into experimental group(20 cases) and control group(20 cases). Among those two groups,the magnesium sulfate therapeutic measure was carried out in the experimental group and the control group was treated without magnesium sulfate. The difference rangeability of level of serum myelin basic protein pre and pro-therapy of both groups was compared. Results For the experimental group, the mean level of serum myelin basic protein in the first day pre-therapy was (8.3 + 2.5) μg/L, and (4.2 ± 1.7) μg/L in 10 days pro-therapy. the csrtrol group was ( 8.0 ± 3.0) μg/L for tite first day pre-therapy,and (6.0 ± 1.4) μg/L in 10 days pro-therapy. The difference rangeability of level of serum myelin basic protein pre and pro-therapy of both groups had statistical significance, compared with the controlled group,the experimental group had lower level of serum myelin basic protein ( t = 1. 231, P = 0. 041 ).Conclusion Magnesium sulfate could significantly decrease the serum level of myelin basic protein for patients with cerebral ischemic stroke,which irdicate that the magnesium sulfate should have neuroprotective effect on patients with cerebral ischemic stroke. Key words: Cerebrovascular Accident, Magnesium sulfate