The dynamic changes of the plasma neuron-specific enolase and myelin basic protein levels and their significance in patients with acute cerebral infarction

Abstract

Objective To investigate the dynamic changes of the plasma neuron-specific enolaee(NSE) and myelin basic protein(MBP)levels and their slgaificance for prognosis in patients with cerebral infarction(CI).Methods The concentrations of NSE and MBP in 75 patients with CI were measured by EUsA within the 24 hours,on the 4th day,on the 7th day and 14th days after the onset,respectively.The results were compared with 40 healthy controls.The correlation among the plasma NSE,MBP level,and the size of the infarction and the neurological function in the patients were explored.Results Compared with those of 40 healthy controls,plasma NSE、MBP levels of the pailents were increazed significantly within the 24 hours and on the 4th day,and especially within the 24 hours.The patients with poor prognosis had higher levels of plasma NSE,MBP within the 24 hours,on the 4th days and on the 7th days than those with good prognosis.There was a positive correlation between the size of the infarction and plasma NSE、MBP levels within the 24 hours and on the 4th days,with the correhtion coefficients of 0.92,0.78(P＜0.001)and 0.82,0.69(P＜0.001)respectively.The decreased clinical neurological deficit scores on the 14th day after the attack were negatively correlated with plasma NSE、MBP levels within the 24 hours and on the 4th day,with the correlation coefficients of-0.51,-0.45(P＜0.001)and-0.47,-0.36(P＜0.001 and 0.01)respectively.Conclusion The plasma levels of NsE and MBP increase obviously in the early stage of the CI.The dynamic changes of the plasma NSE and MBP levels in the patients with CI might reflect to some extent the severity of the neuronal damages and the short-term outcome. Key words: Cerebral infarction; Neuron-specific enolase; Myelin basic protein; Neurological diffct score