The monitoring and prognosis on irritable hyperglycemia in critical diseased children

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Objective To investigate the relationship between levels of blood glucose and organ failure,prognosis in children with critical disease. Methods Venous blood glucose of 106 children with critical disease were analyzed with the method of glucose oxydase after admission and continuously monitored that.The index of hyperglycemia was value of fasting blood glucose ≥6.9 mmol/L. Results The level of glucose of the normal control group, haplo-organ failure group and multiple-organ failure group were (4.8±1.3),(8.3±3.1),(14.2±6.6) mmol/L, respectively (P<0.01).The quantity of organ failure was positive correlation with the level of blood glucose (r=0.461,P<0.01). The blood glucose,K+ of children with critical disease were significant increase as to normal control group(P<0.01), but blood Na+ and Ca2+ were lower in contrast. The level of glucose was positive correlation with the level of blood Na+,Ca2+ (r=-0.343,r=-0.452;P<0.01) and negative correlation with blood K+(r=0.574,P<0.01). The mortalities were 13.06% and 54.54% in corresponding blood glucose levels of less than 15 mmol/L and more than 15 mmol/L. The higher the blood glucose value, the higher the death rate. Conclusions The level of blood glucose in children with critical disease is closely associated with organ failure and prognosis,the higher the blood glucose value is, the pathogenetic condition is more severity, the prognosis is more imminent. Key words: Children with critical disease; Stress-induced hyperglycemia