Abstract
Abstract Six metabolites of quinine were detected in the urine of rabbits given its monohydrochloride orally. Of the metabolites detected, three major ones were quantitatively separated and characterized as 2′-hydroxyquinine, 2′,3-dihydroxyquinine, and 2′,6′-dihydroxycinchonidine. No unchanged alkaloid was detected in the urine. The present results indicate that the most important reaction in the metabolism of the alkaloid in the rabbit is the formation of 2′-carbostyril derivatives.
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