Abstract
Examination of urinary product of rabbits administered with MHB, by filter paper chromatography, indicated that ureide, 3-OH-MHB, 3-keto-MHB, 3-keto-nor-MHB, and unknown compounds (MHB-M (VI)) were excreted. An excellent method for the separation of these compounds is the use of a buffered filter paper and butanol saturated with borate-NaOH buffer (pH 11). For detection of the located metabolites, 1% solution of sodium periodate and 1% solution of potassium permanganate were used and ultraviolet spectrophotometry was adopted for the characterization of barbiturates.
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