Abstract
The interaction of rat liver DNA-cytosine methylase with a variety of naturally-occurring, chemically-modified and synthetic nucleic acid polymers was studied. Binding of the enzyme was affected by the base composition of the synthetic polymers and by alkylation or depurination of naturally-occurring DNAs. It was not affected by deamination of naturally-occurring DNA. Although the rate of methylation of naturally-occurring DNAs to some degree could be correlated with GC content, these differences in rate could not be accounted for by differences in the affinity of binding of enzyme to DNA.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
