Abstract
Background The high-sugar and high-fat diet exerts distinct effects on bone volume and structure, depending on the type of carbohydrates and the amount of lipids. However, the effects of this diet on human bone health remain unexplored. Objective This study examined the effects of a high-sucrose/high-fat diet on the bone health of Sprague–Dawley (SD) rats. Methods Five-week-old SD rats were divided into two groups based on whether they received a normal (CE-2) or high-sucrose/high-fat (HSF) diet: SD＋CE-2 (control) and SD + HSF (treatment) groups (n = 5 rats/group). After 35 weeks of treatment, bone mineral density, structural parameters, and bone metabolism markers were measured. Student's t-test, Welch's t-test, and Mann-Whitney's U-test were used to determine differences between the two groups. Results Femur weight did not differ significantly between the control and treatment groups. The femur area was considerably wider in the treatment group than in the control group. However, trabecular bone density was lower in the treatment group than in the control group. Trabecular volume and node structure number were significantly reduced in the treatment group when compared with those in the control group. Conclusions Although high-sucrose/high-fat diet loading decreased trabecular bone volume and node strut number in SD rats, the diet did not contribute to bone density or structural changes.
Published Version
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