Abstract
Genetic susceptibility may be involved in the onset of recurrent miscarriage. Previous studies have shown that some genetic polymorphisms that regulate cell migration are associated with susceptibility to recurrent miscarriage. The SOX2 overlapping transcript (SOX2OT) may regulate the migration and invasion of multiple tumor cells and is related to susceptibility to various diseases. However, whether lncRNA SOX2OT polymorphisms are related to recurrent miscarriage susceptibility is unclear. Therefore, we investigated the relationship between the lncRNA SOX2OT rs9839776 C>T polymorphism and recurrent miscarriage susceptibility. We recruited 570 subjects with recurrent miscarriage and 578 healthy control subjects from a population in southern China and used the TaqMan method for genotyping. We found a significant association between the rs9839776 CT genotype in the SOX2OT gene and an increased risk for recurrent miscarriage (CT vs CC: adjusted OR = 1.357, 95%CI = 1.065 − 1.728, P = 0.0134). However, we did not observe any significant associations between the recurrent miscarriage risk and the number of miscarriages in different age groups. In conclusion, our study indicated that the rs9839776 CT genotype may contribute to an increased risk of recurrent miscarriage in the southern Chinese population and that rs9839776 may act as a prognostic biomarker in recurrent miscarriage patients. However, an experiment-based study with a larger sample size should be performed to confirm these results.
Highlights
Recurrent miscarriage is defined as the loss of two or more pregnancies with an unknown etiology before the 20th week of gestation with the same male partner [1, 2]
In this case-control study with 570 cases and 578 controls, we evaluated the association of the SOX2 overlapping transcript (SOX2OT) rs9839776 C>T polymorphism with the risk of recurrent miscarriage in a southern Chinese population
We found a significant association between the rs9839776 CT genotype in the SOX2OT gene and an increased risk of recurrent miscarriage
Summary
Recurrent miscarriage is defined as the loss of two or more pregnancies with an unknown etiology before the 20th week of gestation with the same male partner [1, 2]. There are research findings suggesting that recurrent miscarriage is associated with many genetic polymorphisms, including some genes, such as IGF-2 and PAI1 that regulate cell migration [5,6,7]. Increasing research has shown that lncRNAs, such as regulators of transcription, tumorigenesis, cell migration, and invasion, are involved in numerous cellular and carcinogenesis processes [10,11,12,13]. Increasing research has confirmed that lncRNAs are involved in the occurrence and development of spontaneous miscarriage by regulating the migration and invasion of trophoblast cells [14, 15]. Investigating the relationship between lncRNA gene polymorphisms and recurrent miscarriage can help to improve the understanding of the pathogenesis of recurrent miscarriage
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